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1. You have a male who displays the mutant phenotype (and thus carries the mutant allele)...

1. You have a male who displays the mutant phenotype (and thus carries the mutant allele) for the Ckesslj gene, which is located on the mitochondrial DNA. He mated with an unaffected female and has generated 3 offspring (2 females and 1 male).

  1. Draw out this pedigree, making sure you correctly draw/identify affected and unaffected individuals based on the information you have available to you.

  1. For your affected male at the beginning of the story, which of his parents is MOST likely to also express the mutant phenotype? Briefly explain your reasoning.
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Answer #1

The given scenario is an example of cytoplasmic inheritance.
Since the zygote's cytoplasm (including semi-autonomous cell organelles such as mitochondria and chloroplast) is predominantly derived from the mother/female, none of his progeny is affected.
His mother has to be affected for him to exhibit the phenotype.

See the image for the pedigree

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