Question

Which of the following mutations to the G alpha protein could render a G protein–coupled receptor...

Which of the following mutations to the G alpha protein could render a G protein–coupled receptor signaling pathway constitutively active?

a G alpha cannot bind G beta/gamma
b G alpha cannot hydrolyze GTP
c G alpha protein cannot bind GDP
d G alpha protein cannot release GDP
e G alpha protein cannot bind GTP
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Answer #1

G alpha cannot hydrolyze GTP

This mutation to G alpha could render the signalling pathway constitutively functional.

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