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If a drug was administered to a stimulated pre-synaptic neuron that blocked the release of its...

If a drug was administered to a stimulated pre-synaptic neuron that blocked the release of its inhibitory neurotransmitter, what would be the effect on the post-synaptic neuron? explain
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If a drug was administered to a stimulated pre-synaptic neuron that blocked the release of its inhibitory neurotransmitter, the neurotransmitter syntheses are blocked, the amount of neurotransmitters available for release becomes substantially lower, this results in a decrease in neurotransmitter activity. Some drugs can decrease the rate of synthesis of neurotransmitters by affecting the synthetic enzyme(s) for that neurotransmitter.

Drugs which targets the neurotransmitter of major systems affect the whole system. For example in case of Cocaine intake, it blocks the re-uptake of dopamine back into the presynaptic neuron, leaving the neurotransmitter molecules in the synaptic gap for a longer period of time.Thus neurotransmitter continues to bind to the receptors on the postsynaptic neuron resulting in a pleasurable emotional response. The addiction to cocaine leads to the downregulation of some post-synaptic receptors. As the effects of the drug ceases off, a person can become depressed due to decreased probability of the neurotransmitter binding to a receptor.

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