Question

1. The following statement is similar to those you might see on exams. Write a paragraph of 3-5 sentences describing 1) whether the statement is correct or incorrect and 2) the reasoning for your answer. Your answer should demonstrate your understanding of the physiological concepts underlying the statement and be written professionally.

At a chemical synapse, the release of neurotransmitter occurs in response to a graded depolarization of the synaptic terminal.

2. Write a paragraph of 3-5 sentences answering the following questions. Your response should first answer the question and then go onto state physiological interpretation's behind your answer. Paragraphs that demonstrate complete and thorough reasoning will receive full points.

You discover a drug that prevents voltage-gated Na+ channel inactivation gates from opening when they are closed but has no effect on inactivation gates when they are open. What would happen to the action potential in a neuron exposed to this drug? Explain your answer. Assume the neuron is at resting membrane potential (e.g., -70 mV) at the time it is exposed to the drug.

Answer 1

Answer: - 1) This statement is correct onto pront o Reason :- st N oord wat blend at brost e ron This is because a graded depolarization is taking place due to calcium ion inblux. This happen at the Synaptic terminal. As a result of depolarization, the Vesicles containing neurotransmitters are fused with the membrance and release them out of the axon into the Synaptic cleft where it is received by the next neuron, Note: Just i Explain 3-5 sentences so understand clearly and carefully the is correct statement.

2) The answer to this question is that no changes will occurn in the membrance potential of the cell. Since at resting phase, the inactivation, glade of Nat channels are already in open Condition. Therebore, no Effect of the drug is seen on the Nat gates and the membrane is polarized whereas the mem- -brane potential is -70mv. At rising phase, the inactivation gates of nat channels remain open therebole depolarization of membrane takes place. Whereas at talling phase only, the inactivation gatue of na channels are closed and also the drug well prevent voltage - gated flat channels to open but this will not cause the delaying of the after hyperpolarization of the membrane and also will not change the action potential of the membrane. = = please Rate my Answer Thank you...