The acetylcholinesterase enzyme functions to break down acetylcholine in a synapse. How would an antagonist of...
The acetylcholinesterase enzyme functions to break down acetylcholine in a synapse. How would an antagonist of acetycholinestrrase affect the half life of acetylcholine in a synapse?
Homework Answers
The presence of acetylcholinesterase inhibitor will inhibit the acetylcholine break down, as a result of which the half-life of acetylcholine, which is 1 to 2 milliseconds, will be increased. Acetylcholine will be accumulated in the synapse causing continuous stimulation of impulse conduction or continuous firing of the nerves at the synapse. This leads to rapid twitching of some muscles, paralyzed breathing, etc and finally death.
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The acetylcholinesterase enzyme functions to break
down acetylcholine in a synapse. How would an antagonist of...
Acetylcholine is the substrate for the enzyme acetylcholinesterase. 1. Suggest what sort of binding interactions could...
Acetylcholine is the substrate for the enzyme
acetylcholinesterase.
1. Suggest what sort of binding interactions could be involved
in holding acetylcholine to the active site.
2. The ester bond of acetylcholine is hydrolysed by
acetylcholinesterase. Suggest a mechanism by which the enzyme
catalyses this reaction.
3. Suggest how binding interactions might make acetylcholine
more susceptible to hydrolysis.
4. Structure I is an agonist which binds to the cholinergic
receptor and mimics the action of the natural ligand acetylcholine.
Structure II,...
Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine and other choline esters that act...
Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine and other choline esters that act as neurotransmitters. Acetylcholinesterase is one of the most viable therapeutic targets to date for symptomatic improvement in Alzheimer's disease as cholinergic deficit is a common finding in Alzheimer's disease. A new compound that acts as an acetylcholinesterase inhibitor is in preclinical drug development and being assessed as a possible treatment for Alzheimer's disease. Which of the following parameters would give an indication about the...
19. Acetylcholinesterase is an enzyme with a very high frequency of appearance in BMB 401 worksheets. (Recall question...
19. Acetylcholinesterase is an enzyme with a very high frequency of appearance in BMB 401 worksheets. (Recall question #10, above.) This enzyme hydrolyzes acetylcholine. The activity of acetylcholinesterase is important for modulating synaptic transmission. Some bioweapons (nerve HO active site of the acetylcholinesterase (anionic site +esteric site), and based on what you know about serine reactivity, how do you think the nerve agent works? Serine Estenic Se Acetylcholinesterase How many functional groups in the peptide MDFGRKCDE can gain or lose...
We need the assistance of enzymes such as choline acetyltransferase (ChAT) to make acetylcholine because there...
We need the assistance of enzymes such as choline acetyltransferase (ChAT) to make acetylcholine because there _____ a gene for acetylcholine. Neurons typically communicate with each other via _______ signals in the form of neurotransmitters like acetylcholine. We also need other enzymes to break down excess neurotransmitter. If we are exposed to acetylcholinesterase inhibitors, then we would expect to see a(n) _________ in the amount of acetylcholine available in the synaptic cleft. A)Is not; electrical; decrease B) Is; electrical; increase...
Resting potential has been drawn for you. Continue that line to show what would happen to...
Resting potential has been drawn for you. Continue that line to show what would happen to membrane potential in the POSTsynaptic muscle cell if the person was exposed to cyclosarin. Cyclosarin prevents acetylcholinesterase (the enzyme that breaks down the neurotransmitter) from breaking down acetylcholine (the neurotransmitter). Membrane Potential * Clear sketch Submit response I Switch to text response
1. a) If one were to decrease the enzyme concentration by half, how would this affect...
1. a) If one were to decrease the enzyme concentration by half, how would this affect the Vmaxvalue? Explain why this is so. What assumption are we making in regards to the relative amounts of substrate to enzyme? b) Is the turnover rate (kcat value) of an enzyme expected to change if the enzyme concentration was decreased by half? Briefly explain. c) Is the turnover rate (kcat value) of an enzyme expected to change in the presence of a competitive...
Putting catalase enzyme in a pH 12 solution will have no effect denature (break down/change the...
Putting catalase enzyme in a pH 12 solution will have no effect denature (break down/change the shape of) the enzyme speed up the reaction rate of catalase
Putting catalase enzyme in a pH 12 solution will have no effect denature (break down/change the...
Putting catalase enzyme in a pH 12 solution will have no effect denature (break down/change the shape of) the enzyme speed up the reaction rate of catalase
How does acetylcholine esterase interact with the ECM ... are there specific proteins that are required...
How does acetylcholine esterase interact with the ECM ... are there specific proteins that are required for its expression? how would you expect the enzyme to be translated/transported to the ECM and which of the ECM proteins interact with the esterase?
2. Long-term Potentiation is a process that strengthens the transmission of a single synapse in a circuit. This is achieved when pre-synaptic cells and post-synaptic cells fire action potentials at t...
2. Long-term Potentiation is a process that strengthens the transmission of a single synapse in a circuit. This is achieved when pre-synaptic cells and post-synaptic cells fire action potentials at the same time. Usually multiple pre-synaptic cells synapse onto one post-synaptic cell, increasing the probability of inducing an action potential in the post- synaptic cell. You may need to refer to your textbooks or online resources for this question, as we do not cover this in explicit detail in class....
Acetylcholine is the substrate for the enzyme
acetylcholinesterase.
1. Suggest what sort of binding interactions could be involved
in holding acetylcholine to the active site.
2. The ester bond of acetylcholine is hydrolysed by
acetylcholinesterase. Suggest a mechanism by which the enzyme
catalyses this reaction.
3. Suggest how binding interactions might make acetylcholine
more susceptible to hydrolysis.
4. Structure I is an agonist which binds to the cholinergic
receptor and mimics the action of the natural ligand acetylcholine.
Structure II,...
Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine and other choline esters that act as neurotransmitters. Acetylcholinesterase is one of the most viable therapeutic targets to date for symptomatic improvement in Alzheimer's disease as cholinergic deficit is a common finding in Alzheimer's disease. A new compound that acts as an acetylcholinesterase inhibitor is in preclinical drug development and being assessed as a possible treatment for Alzheimer's disease. Which of the following parameters would give an indication about the...
19. Acetylcholinesterase is an enzyme with a very high frequency of appearance in BMB 401 worksheets. (Recall question #10, above.) This enzyme hydrolyzes acetylcholine. The activity of acetylcholinesterase is important for modulating synaptic transmission. Some bioweapons (nerve HO active site of the acetylcholinesterase (anionic site +esteric site), and based on what you know about serine reactivity, how do you think the nerve agent works? Serine Estenic Se Acetylcholinesterase How many functional groups in the peptide MDFGRKCDE can gain or lose...
Resting potential has been drawn for you. Continue that line to show what would happen to membrane potential in the POSTsynaptic muscle cell if the person was exposed to cyclosarin. Cyclosarin prevents acetylcholinesterase (the enzyme that breaks down the neurotransmitter) from breaking down acetylcholine (the neurotransmitter). Membrane Potential * Clear sketch Submit response I Switch to text response
Putting catalase enzyme in a pH 12 solution will have no effect denature (break down/change the shape of) the enzyme speed up the reaction rate of catalase
Putting catalase enzyme in a pH 12 solution will have no effect denature (break down/change the shape of) the enzyme speed up the reaction rate of catalase
2. Long-term Potentiation is a process that strengthens the transmission of a single synapse in a circuit. This is achieved when pre-synaptic cells and post-synaptic cells fire action potentials at the same time. Usually multiple pre-synaptic cells synapse onto one post-synaptic cell, increasing the probability of inducing an action potential in the post- synaptic cell. You may need to refer to your textbooks or online resources for this question, as we do not cover this in explicit detail in class....
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