Why is it unwise to begin addition of the solution of carbonyl compound to the Grignard reagent before the latter has cooled to room temperature?
First of all, the Grignard compound by itself can generate explosion when heat is not controlled (too hot). So you should be able to stable it before adding the carbonyl compound to it.
Another strong reason is that the addition of the carbonyl compound to the Grignard compound is a reaction that is extremely exothermic. You already are handling an exothermic reaction, but by adding the carbonyl compound you would be generating more heat, which can be dangerous and difficult to control.
Why is it unwise to begin addition of the solution of carbonyl compound to the Grignard...
?? Three reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.) Ketone reaction Ester reaction Acyl halide reaction Above, keep in mind that two equivalents of the Grignard reagent are utilized. What is the intermediate product resulting from the addition...
What Grignard reagent and what carbonyl compound might you start with to prepare the following alcohols? (a) (b) (c) (d) (e) (f) 3. What Grignard reagent and what carbonyl compound might you start with to prepare the following alcohols? OH CH3CHCH2CH3 CH3CH2CHCH2CH HC CH2OH OH
8. Give the Grignard and Carbonyl compound needed to make each of alcohols. (6 points, 2 each) nd needed to make each of the following you - 9. Circle the compounds that could not be made into a Grignard Reagent. Br 10. Show how you could convert the compound below into a Grignard reagent without having it destroy itself. (4 points)
Identify three possible routes to synthesize the target alcohol by nucleophilic addition of Grignard reagent to a carbonyl compound. Target alcohol OH -¢-CH2CH2CH3 CH2CH2CH3
Three reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.) Three reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to...
Organocuprates predominantly react to give 1,4-addition products with a,ß-unsaturated carbonyl species, while Grignard reagents often add to the carbonyl, in a process referred to as 1,2-addition. To increase the yield of 1,4-addition products, Cul is added to convert an easily prepared Grignard reagent into an organocuprate reagent in situ. MgBr Cul, THF, -30°C For this reaction draw the structure of the 1,2-addition product prepared without Cul , including stereochemistry, assuming that the major product is derived from the more stable...
Organocuprates predominantly react to give 1,4-addition products with a.ß-unsaturated carbonyl species, while Grignard reagents often add to the carbonyl, in a process referred to as 1,2-addition. To increase the yield of 1,4-addition products, Cul is added to convert an easily prepared Grignard reagent into an organocuprate reagent in situ. Sa MgBr Cul, THF, -30°C For this reaction draw the structure of the 1,2-addition product prepared without Cul, including stereochemistry, assuming that the major product is derived from the more stable...
Two reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.) Two reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to...
Problem 1. Synthesize the following alkene through the Wittig reaction of a carbonyl compound and a Wittig reagent. 2,3-diphenyl-2-butene 2. Predict the products of the following reactions. Casco CHCH.CHCH, CHCH.CH но ats ОО 2.0 CH,CHACHCH,CHCHOCH.CH, CH 3. A useful and general method for the synthesis of alcohols is the addition of Grignard reagents to carbonyl compounds. Show what Grignard reagent and what carbonyl compound you would start with to prepare the alcohol below. List all possibilities. 2-methyl--butanol 2-METHYL-2- BOTANIC
?? Three reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H~ is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.) Ketone reaction