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1. Cholesterol is not metabolized for energy. Discuss the roles of cholesterol, site of synthesis, and...

1. Cholesterol is not metabolized for energy. Discuss the roles of cholesterol, site of synthesis, and its turnover.

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Answer #1

Cholesterol:

  • It is a lipid.
  • It is a 27 C compound.
  • It is a long-chain fatty acid, is made from acetyl-CoA,
  • It is an important component of cell membrane. As it maintains the fluidity of the cell membranes.
  • It plays a role as a temperature buffer in the membrane.
  • It is a precursor for steroidal hormones.
  • Precursor for Vitamin D.

Site of synthesis:

  • In vertebrates mostly the synthesis of cholesterol occurs in a Liver.
  • In small fraction also takes place in Membranes on hepatocytes.
  • Export form of cholesterol is biliary cholesterol, bile acids, or cholesteryl esters.

The turnover number of cholesterol is 0.6 to 2gm/day.

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