Question

whats histone crosstalk

Answer 1

Ans. The molecule histone is the major component of genetic material of a cell. DNA combines with histones to form small packages called nucleosomes. Histone is a basic protein and it exists as octamer. The various components of a histone molecule interacts among themselves by transfer of groups. They may also interact with component of another histone molecule which will modify the structure of the latter. This event is called histone crosstalk.

The transfer of a group can be exemplified by transfer of an acetyl group or phosphate group to serine amino acid of another component of a histone octamer. Phosphorylation and dephosphorylation events are common outcomes of crosstalk event.