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Organic Chemistry: Question: Why might salt ibuprofen lysinate be expected to be more soluble than ibuprofen...

Organic Chemistry:

Question: Why might salt ibuprofen lysinate be expected to be more soluble than ibuprofen itself?

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Answer #1

Ans : Ibuprofen contains a polar carboxyl group (-COOH) but the non-polar alkyl group and benzene ring which significantly reduces it's polarity.So, the Ibuprofen is quite non-polar while water is a polar molecule.Hence, Ibuprofen is insoluble in water.

On the other hand, the salt Ibuprofen lysinate is soluble in water because it is an ionic form and can form ion-dipole bonds with water.

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