Which of the following is CLINICAL EVIDENCE supporting a role of macrophages in tumour progression? A...
Which of the following is CLINICAL EVIDENCE supporting a role of
macrophages in tumour progression?
A High levels of circulating monocytes correlate with low overall
survival of cancer patients
B High levels of TAM correlate with low overall survival of cancer
patients
C TAM infiltration identifies the tumour sub-type
D Presence of specific tumour-associated mutations
E Presence of specific macrophage-associated mutations
Homework Answers
The correct answer is:
B. High levels of TAM (tumor-associated macrophages) correlate with low overall survival of cancer patients.
Clinical evidence has shown that high levels of TAM infiltration in tumors are associated with a poorer prognosis and lower overall survival rates in cancer patients. TAMs can promote tumor progression by promoting angiogenesis, suppressing immune responses, and facilitating tumor cell invasion and metastasis. Their presence and functional role in the tumor microenvironment have been linked to tumor aggressiveness and poor treatment outcomes. Therefore, high levels of TAMs are considered clinical evidence supporting a role of macrophages in tumor progression.
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Which of the following is CLINICAL EVIDENCE supporting a role of
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