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What is the specific mechanism of action for temozolomide? (doesn't have to be very in depth,...

What is the specific mechanism of action for temozolomide? (doesn't have to be very in depth, just an overview)

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Temozolomide is the drug used in the treatment of brain cancer, etc. It's mechanism of action is based on ability of its metabolites to deposit methyl groups on guanine bases of DNA.

Temozolomide gets converted into MTIC i.e. 3-methyl-(triazen-1-yl) imidazole-4-carboxamide which methylates DNA as a result cellular repair mechanism cannot adjust due to which DNA break down into small pieces resulting death of cells.

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