Question

Below, you can find a partial sequence of last 30 amino acids of a certain protein (amino acids, single-letter code). There are also mutated sequences of the same protein. Explain which mutations could have happened. (pay attention to the sequence length and the sequence itself) (25)

Original                 GVLSEGEWQLVLHVWAKVEADVAGHGQDIL

Mutant 1             GVLSEGEWQLVLHV

Mutant 2             GVLSEGEWQLVHVWAKVEADVAGHGQDIL

Mutant 3             GVLQHDAWQLVLHVWAKVEADVAGHGQDIL

Mutant 4             GVLSEGEWQLVLHVWAKVEAWLWVMGHEVMLQ

Mutant 5             GVLSEGEWQLVLHVWAKVEADVAGHGQDILWALWQAEVGQLIGH

Answer 1

mutation 1 is deletion mutation

Mutation 2 is deletion mutation but it is only in one point, so it is called point mutation.

Mutation 3 is substitution mutation

Mutation 4 is also substitution mutation

Mutation 5 is insertion mutation.

Please refer to the image after reading this. Hit thumps up if you feel convinced!