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If Ca2+Ca2+ is often bound on the surface of a protein by carboxylic acid functional groups....

If Ca2+Ca2+ is often bound on the surface of a protein by carboxylic acid functional groups. If the pKa of a particular −COOH−COOH group is 4.4, would you predict Ca2+Ca2+ to be most tightly bound at pHpH 7, pHpH 4.4, or pHpH 3?

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Answer #1

At pH =7

For binding of an ion to the acid it must exist in deprotonated form. mostly deprotonated form exist at ph=7, therefore calcium will be tightly bound at ph=7 because almost whole the salt will be deprotonated.

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