Question

just answer it. DO NOT WORRY ABOUT CONCENTRATION AMOUNT

1. List two strategies that might be employed if the desired concentration of a prescribed drug solution is above the drug’s solubility.

2. When making solutions, co-solvents should always be added in order of decreasing solubility. Explain the rationale for this procedure.

3. A compounder should use solubility data as a guide for formulation development. Explain the rationale for this approach.

Answer 1

1. Particle reduction like nanosuspension ,microionization ,drug dispersions in carriers like eutectic mixtures,solid dispersions ,solid solutions can be used

Change of pH ,buffering etc

Ex : supercritical fluid process

2.cosolvents are the mixtures of miscible Solvents often used to water which can dramatically change the solubility of poor soluble drugs. Cosolvents works by reducing the interfacial surface tension between the aqueous solution and hydrophobic solute. Cosolvents usually have both hydrophobic and hydrophilic groups .while hydrophilic groups ensure water miscibility , hydrophobic hydrocarbon groups interfere with waters hydrogen bonding network reducing the overall attraction of water .By disrupting water self association cosolvents reduce the water ability to Squeeze out nonpolar and hydrophobic compounds thus increasing solubility.

3.