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Make a Muscle Contraction Flowchart. Show what machinery is used such as protein and structures, what...

Make a Muscle Contraction Flowchart. Show what machinery is used such as protein and structures, what steps occur, and changes in I band, H zone, A band, etc.

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Muscle contraction :

Muscle contraction mechanism is best explained sliding filament theory proposed by Jean Hanson and Hugh Huxley.

According to this theory contraction of muscle fibre takes place by sliding of thin filaments over /between the thick filaments.

Steps in muscle contraction:

1) Excitation of muscle : Muscle contraction starts when a stimulus from central nervous system (CNS) reaches neuromuscular junction via motor neurone.

Then neuromuscular junction release acetylcholine Which generates action potential in sarcolemma which spreads to triad system through T- tubules, then release of calcium ions from cisternae of sarcoplasmic reticulum take place.

2) Formation of cross bridges: The released calcium binds to subunit Tn-c of the troponin of thin filament. Then moving of troponin and tropomyosim complex away from active sites of actin molecules take place.

Since active site is know exposed to head of myosin ,myosin binds to active sites and form cross bridge and P​​1 is released.This binding is promoted by ATPase

3) Power stroke : formed cross bridge pulls actin filaments to the centre of A- band ,z-lines attached to these also pulled inward from both sides causing shortening of sarcomere - contraction of muscle take place.

4) Recovery stroke : The myosin relaxes by releasing ADP and cross bridge is broken by binding of new ATP molecule to the myosin head .again ATPase hydrolyses ATP and cycle repeats causing further sliding.

5) Relaxation of muscle: when motor Impulses stop , calcium ions are pumped back and active sites are closed and cause z- lines to revert to their original position and cause muscle relaxation.

CHANGES IN A- BAND : A- band does not shorten in length during contraction .it retains the same length but they move closer during contraction.

CHANGES IN I-Band : The I band gets reduction in size and length

CHANGES IN H- ZONE : it is central region of A zone .it contains myosin ( thick filaments) it shortens during muscle contraction due to ovelapping of actin and myosin,once muscle is totaly contracted ,H- zone dissapears.

CHANGES IN Z-LINES : These ars pulled inward during muscle contraction from both sides causing shortening of sarcomere .

Actin and myosin are the structures used in muscle contraction : These are the contractile proteins.

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