Where are the N termini of the histones localized in a nucleosome?
Histones are proteins that help in packaging of DNA into structural units known as nucleosomes. Two of the common regions of each histone (H2A, H2B, H3, and H4) are the C terminal histone fold and the N terminal tails. The N terminal tails are very important in maintaining histone -DNA interactions and nucleosome stability. They have been found to affect inter as well as intra nucleosomal interactions.
The minor grooves of the two DNA strands create a channel
through which the N-terminal tails of the histone H3 and H2B pass,
which are found extended beyond the DNA at every 20 base pairs.
Moreover, in the H4 histone (which comprises a region of highly
basic amino acids) the N terminal tail interacts with the surface
of H2A-H2B dimer (which has highly acidic surface region) of
another nucleosome. These interaction contribute for the higher
stability of the nucleosome structure.
Which of the following is not true for histones? A. They are associated with the nucleosome. B. H1, H2, and H4 form the nucleosome core. C. They are found in the nucleus. D. H1 functions as a monomer.
Which does not describe eukaryotic histones in a nucleosome structure? A. A core histone plus a linker histone octamer B. A core histone octamer plus a linker histone C. A core histone octamer plus 2 linker histones D. A core histone nonamer E. A core histone heptamer plus a linker histone
Mention what modification patterns in histones are present in nucleosome during mitosis. Explain how such modification patterns affect chromatin structure in mitosis
31. How many different types of histones are found in the nucleosome that packages mitochondrial DNA? A) zero B) one C) two D) three E) four 32. The theory states that the ancestors of mitochondria and chloroplasts were free living bacteria A) phylogenetic B) endosymbiotic C) cell D) cytoplasmic inheritance E) old world 33. The presence of more than one variation of DNA in the organelles of a single cell is called: A) homoplasmy. B) heteroplasmy. C) hemiplasmy. D) pseudoplasmy....
The letter A indicates _____. Question #25 The letter A indicates _____. Question #25 supercoils a nucleosome a DNA double helix histones loops SubmitMy AnswersGive Up Part B Where would RNA polymerase attach? Question #26 Where would RNA polymerase attach? Question #26 A B C A and B B and C SubmitMy AnswersGive Up Part C The letter C indicates _____. Question #27 The letter C indicates _____. Question #27 supercoils a nucleosome a DNA double helix histones loops SubmitMy...
Nucleosome positioning along the DNA can influence where transcriptional regulatory proteins are able to bind DNA. If a nucleosome is bound to an enhancer sequence, it may outcompete a regulatory protein from binding the same sequence. Conversely, if an enhancer sequence is in the linker DNA where the nucleosome is absent, the regulatory protein does not have to compete with the nucleosome. The position of the nucleosome can alter the accessibility of a sequence of DNA to DNA binding proteins....
QUESTION 1 A nucleosome consists of A. a cluster of histone proteins that are wrapped around the DNA double helix. B. two peptides each of histones H2A, H2B, H3 and H4, wrapped by the DNA double helix. the DNA polymerase complex and the Okazaki fragments of approximately 200 bases in C. length. D. clusters of ribosomal large subunits and small subunits bound to the DNA double helix. E. one of each of the 5 types (H1 - H4) of histone...
The molecule of n-butane contains localized bonds Select one: True False
Where in the cell is the GEF for Ran GTPase localized? What is its role in the transport of proteins? What do mitochondrial and ER signal peptidases have in common? How do they differ? (Think about their location within the organelle.)
Indicate whether the unshared electron pairs present in these structures are “localized” or “delocalized” and draw additional resonance structures where possible.