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Where are the N termini of the histones localized in a nucleosome?

Where are the N termini of the histones localized in a nucleosome?

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Histones are proteins that help in packaging of DNA into structural units known as nucleosomes. Two of the common regions of each histone (H2A, H2B, H3, and H4) are the C terminal histone fold and the N terminal tails. The N terminal tails are very important in maintaining histone -DNA interactions and nucleosome stability. They have been found to affect inter as well as intra nucleosomal interactions.

The minor grooves of the two DNA strands create a channel through which the N-terminal tails of the histone H3 and H2B pass, which are found extended beyond the DNA at every 20 base pairs. Moreover, in the H4 histone (which comprises a region of highly basic amino acids) the N terminal tail interacts with the surface of H2A-H2B dimer (which has highly acidic surface region) of another nucleosome. These interaction contribute for the higher stability of the nucleosome structure.

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