1. How and why could a protein change with a change in one amino acid? (Hint: think of Hemoglobin S)
A protein is essentially a polymer of amino acids. The properties of proteins, thus, depend largely on the composition of amino acids. Amino acids can be hydrophobic, hydrophilic or charged (negatively or positively). These properties of amino acids make proteins to function properly. Even a change in a single amino acid can make the protein lose its functional as well as structural properties. This can be seen in the case of sickle cell trait where a missense mutation replaces glutamic acid with another hydrophobic amino acid- valine at the 6th position of beta-globin chain. This results in aggregation of hemoglobin in low oxygen conditions which promote distortion of red blood cells. Thus, in sickle cell trait, the RBCs lose their original shape.
1. How and why could a protein change with a change in one amino acid? (Hint:...
* 2.1 Describe different ways to classify amino acids and predict whether change in amino acid is likely to disrupt protein structure * 2.2 Compare and contrast the different levels of protein structure and how they relate to one another * 2.3 Describe the biochemical information that determines the final three-dimensional structure and explain what powers the formation of this structure * 2.4 Explain how structure determines function in general and using hemoglobin and myoglobin as specific examples. * 2.5...
1. How can protein folding affect protein function? 2. How can amino acid sequence affect protein function? 3. How can an amino acid sequence (primary sequence) dictate 3D protein structure?
Explain how/why the amino acid glycine and proline significantly impact the evolution of protein structure and function.
Discuss how the amino acid distribution of a protein that is embedded in the lipid bilayer of the cell ( a membrane protein) differs from the amino acid distribution in globular protein.
what is soy protein? how to make amino acid from soy protein?
For which codon(s) of isoleucine could a single base change account for an amino acid change to methionine? Select all that apply. Select all that apply. A. AUC B. AUU C. AUA D. AUG E.none of these codons
Given a protein amino acid sequence (written out, 1 letter abbreviation, about 700 amino acids), how do i identify the N and C terminals? I know that N terminal is a free amine group and C is a free carboxyl group, but how do i know it is free? How do i identify it?
An amino acid is to a protein as a _______ is to a nucleic acid. Multiple Choice glucose glycerol nucleotide fatty acid cellulose
1. a) Consider a symporter protein that functions to bring in a specific amino acid into the cell against its gradient. Which of the following ion gradients could this protein use as an energy source? b) Consider an antiporter protein that functions to transport a molecule out of the cell against its gradient. Which of the following ion gradients could this protein use as an energy source? c) Consider a symporter protein that functions to transport a molecule out of...
Please explain why one amino acid may have a different pK in different proteins or in different regions of the same protein.