Question

A) Explain the difference between consitutive and regulated release?
B) On a graph (x axis= time, y axis= hormone) draw the elimination profile of each of these two kinds of hormones.

Answer 1

Ans.) (A) In consitutive type of release mechanism proteins are continually secreted by cell. In this case protein release donot depend on any external factor or stimulus. It is being released continuosly and their concentration is blood plasma is nearly constant as there is equillibrium in their elimination and addition.

Regulated release is the type enzyme/protein release mechanism where any external siganl or stimulus leads to secretion of protein by the cell. External signal leads to generation of intra-cellular signalling and hence more is only released in regulated mode. Over certain time these proteins degrade or eliminated from system and hence their concentration decreases.

Ans.) (B)

In regulated release, the hormone concentration will increase for certain time when signal for signal is released and then will decrease. However in case of consitutive release there is nearly constant concentration due to continuos secretion even in absence of any signal or stimulus.