Question

A base, with a pKa of 9.5 on a primary amino group, can diffuse across biological...

A base, with a pKa of 9.5 on a primary amino group, can diffuse across biological membranes when it carries no net charge. What percentage of the base would be in such a form at close to physiological pH, 7.5? Explain your answer and how you got it.

A. 100%

B. 90%

C. 50%

D. 10%

E. 1%

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Answer #1

it will be in the same basic form at pH 7.5, the charge of the amino acid remain unaltered at physiological pH 7.0. it is a neutral pH at which the charge of amino acid remains unaffected. therefore the base is unaltered at this pH.it remains in the same form of 100%

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