2) What are defensins? And why do hypomorphs of NOD1/2 (i.e. less functional NOD1/2 proteins)
promote small intestinal inflammation in Crohn’s patients? (4 pts)
First of all, Defensins are protein crystals that are found in animals (vertebrates and invertebrates) and some plans which work as host defences against fungi, bacteria and some virus. They can be secreted by neutrophils or macrophages which are a part of WBC section of your blood.
Now about the hypomorphs NOD 1/2 can create inflammation in the small intestine of Crohn's patients as it functions in defence of the intestinal epithelium. And in crohn's disease, frequent aberrations leads to a permanent inflammation in the intestine. So, remember, the more the infection on a particular site, the more the inflammation.
2) What are defensins? And why do hypomorphs of NOD1/2 (i.e. less functional NOD1/2 proteins) promote...
Crohn’s disease is an inflammatory bowel disease most often localized to the lower part of the small intestines. It is thought that Crohn’s disease could be an autoimmune disease, because chronic inflammation and activated immune cells are found deep into the intestinal tissue of Crohn’s patients. The chronic inflammation causes the small intestines to swell, which can lead to abdominal pain, diarrhea, gastrointestinal bleeding, and/or weight loss (due to malnutrition), and if the inflammation is severe enough, the small intestine...
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