What is the net reaction that HIV- protease enzyme catalyzes. In other words list the substrates...
What is the net reaction that HIV- protease enzyme catalyzes. In other words list the substrates and
products.
Homework Answers
Proteases cleave the peptide bond linking amino acids in a protein. They hydrolyse proteins.
Reaction of HIV protease:
Substrate: [170-Ile-Pro-Phe-Asp-Leu-164]
Products: [170-Ile-Pro], [Phe-Asp-Leu-164]
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What is the net reaction that HIV- protease enzyme catalyzes. In
other words list the substrates...
14. HIV-1 Protease is an enzyme made by HIV that hydrolyzes the long viral polyprotein into...
14. HIV-1 Protease is an enzyme made by HIV that hydrolyzes the long viral polyprotein into their functional protein components. HIV patients are treated with inhibitors of HIV Protease, which in turn inhibit HIV replication. Two competitive inhibitors of HIV-1 Protease are saquinavir (K = 0.40 nM) and ritonavir (K1 = 0.015 nM). (K, are dissociation constants for the reaction IE + I + E, where I is the inhibitor and E is HIV Protease.) a) Which would have a...
The HIV protease enzyme uses a general acid-base catalysis mechanism to cleave viral polypeptides but does...
The HIV protease enzyme uses a general acid-base catalysis mechanism to cleave viral polypeptides but does not use a covalent catalysis. This enzyme functions optimally in the pH range of 4-6. Due to the specific amino acids involved in this catalysis, HIV protease is a member of which subclass of proteases? Select one: A. metalloproteases B. aspartyl proteases C. serine proteases D. lysine proteases E. cysteine proteases
An enzyme catalyzes the reaction M↽−−⇀N . An enzyme catalyzes the reaction M = N. The...
An enzyme catalyzes the reaction M↽−−⇀N .
An enzyme catalyzes the reaction M = N. The enzyme is present at a concentration of 3.5 nM, and the Vmax is 1.9 uM -. The Km for substrate M is 2.9 uM. Calculate kcat kcat = 542.86 What values of Vmax and Km would be observed in the presence of sufficient amounts of an uncompetitive inhibitor to generate an a' of 1.5? apparent Vmax = 0.526 UM s-1 apparent Km = 1.2
what is the name of the enzyme that catalyzes the reaction shown below? 14.) (4 pts)...
what is the name of the enzyme that catalyzes the reaction shown
below?
14.) (4 pts) What is the name of the enzyme that catalyzes the reaction shown below? Glyceraldehyde 3-P + Sedoheptulose 7-P. Xylulose 5-P + Ribose 5-P. This enzyme requires the following coenzyme. What is it? Draw the mechanism of this reaction converting reactants into products. Draw the structure of any relevant intermediates. You may use B-H and B: for the general acid / base groups. PUSH ARROWS!...
2. A protease is an enzyme that catalyzes the hydrolysis of proteins. These usually have histidine...
2. A protease is an enzyme that catalyzes the hydrolysis of proteins. These usually have histidine (his) in the active site as well as arginine(arg). Below is a "ribbon" model of its structure. Asp1022 ser Gly133 His5 IP a. Look up his and arg and show the calculations for establishing the charge on these amino acids (within the protein) at pH 3 and 7. b. Label with arrows, on the above model the types of secondary structure within this protein....
is meant by a "pacemaker" enzyme is an enume that catalyzes the fastest reaction in a...
is meant by a "pacemaker" enzyme is an enume that catalyzes the fastest reaction in a pathway A It is an nuryme the catalyzes the slowest reaction in a pathway c) It is in en ryme that requires a significant energy source to function D) It is an enzyme that requires a co-factor to function E) It is an enzyme that is covalently modified during the reaction process 24. What is the difference bet between the lock-and-key and the induced-fit...
An enzyme catalyzes a reaction with a Km of 9.50 and a Vmax of 1.75 An...
An enzyme catalyzes a reaction with a Km of 9.50 and a Vmax of
1.75
An enzyme catalyzes a reaction with a K_m of 9.50 mM and a of 1.75 mM- s^-1. Calculate the reaction velocity, V_0, for the following substrate concentrations. 2.50 mM 9.50 mM 12.0 mM
5. For each enzyme-catalyzes reaction below, state the specific class of enzyme that catalyzes it and...
5. For each enzyme-catalyzes reaction below, state the specific class of enzyme that catalyzes it and give the first and/or second digit of its EC number, as indicated. (12 pts - 3 ea.) a) Isan → COASH + HO class: EC b) ATP AMAT hesreot + COASH class: EC ~ +10 lingen Ho class: EC MASH+ it is a mere class: EC
5. For each enzyme-catalyzes reaction below, state the specific class of enzyme that catalyzes it and...
5. For each enzyme-catalyzes reaction below, state the specific class of enzyme that catalyzes it and give the first and/or second digit of its EC number, as indicated. (12 pts - 3 ea.) a) or Ascan onore → CASH + class: EC b) ATP AMP+R olstot + COASH class: EC c) of class: EC is met mens de class: EC-
Human immunodeficiency virus 1 (HIV-1) encodes a protease (MW 21,500 g/mol) that is essential for the...
Human immunodeficiency virus 1 (HIV-1) encodes a protease (MW 21,500 g/mol) that is essential for the assembly and maturation of the virus. The protease catalyzes the hydrolysis of a heptapeptide substrate with a kcat of 1000 s-1 and a Km of 0.075 M. a) Calculate Vmax (M/s) for substrate hydrolysis when HIV-1 protease is present at 0.20 mg/mL. Give your answer in the format 5.4 E -6 (a hypothetical example) with 2 sig figs -- do not show units. When...
14. HIV-1 Protease is an enzyme made by HIV that hydrolyzes the long viral polyprotein into their functional protein components. HIV patients are treated with inhibitors of HIV Protease, which in turn inhibit HIV replication. Two competitive inhibitors of HIV-1 Protease are saquinavir (K = 0.40 nM) and ritonavir (K1 = 0.015 nM). (K, are dissociation constants for the reaction IE + I + E, where I is the inhibitor and E is HIV Protease.) a) Which would have a...
The HIV protease enzyme uses a general acid-base catalysis mechanism to cleave viral polypeptides but does not use a covalent catalysis. This enzyme functions optimally in the pH range of 4-6. Due to the specific amino acids involved in this catalysis, HIV protease is a member of which subclass of proteases? Select one: A. metalloproteases B. aspartyl proteases C. serine proteases D. lysine proteases E. cysteine proteases
An enzyme catalyzes the reaction M↽−−⇀N .
An enzyme catalyzes the reaction M = N. The enzyme is present at a concentration of 3.5 nM, and the Vmax is 1.9 uM -. The Km for substrate M is 2.9 uM. Calculate kcat kcat = 542.86 What values of Vmax and Km would be observed in the presence of sufficient amounts of an uncompetitive inhibitor to generate an a' of 1.5? apparent Vmax = 0.526 UM s-1 apparent Km = 1.2
what is the name of the enzyme that catalyzes the reaction shown
below?
14.) (4 pts) What is the name of the enzyme that catalyzes the reaction shown below? Glyceraldehyde 3-P + Sedoheptulose 7-P. Xylulose 5-P + Ribose 5-P. This enzyme requires the following coenzyme. What is it? Draw the mechanism of this reaction converting reactants into products. Draw the structure of any relevant intermediates. You may use B-H and B: for the general acid / base groups. PUSH ARROWS!...
2. A protease is an enzyme that catalyzes the hydrolysis of proteins. These usually have histidine (his) in the active site as well as arginine(arg). Below is a "ribbon" model of its structure. Asp1022 ser Gly133 His5 IP a. Look up his and arg and show the calculations for establishing the charge on these amino acids (within the protein) at pH 3 and 7. b. Label with arrows, on the above model the types of secondary structure within this protein....
is meant by a "pacemaker" enzyme is an enume that catalyzes the fastest reaction in a pathway A It is an nuryme the catalyzes the slowest reaction in a pathway c) It is in en ryme that requires a significant energy source to function D) It is an enzyme that requires a co-factor to function E) It is an enzyme that is covalently modified during the reaction process 24. What is the difference bet between the lock-and-key and the induced-fit...
An enzyme catalyzes a reaction with a Km of 9.50 and a Vmax of
1.75
An enzyme catalyzes a reaction with a K_m of 9.50 mM and a of 1.75 mM- s^-1. Calculate the reaction velocity, V_0, for the following substrate concentrations. 2.50 mM 9.50 mM 12.0 mM
5. For each enzyme-catalyzes reaction below, state the specific class of enzyme that catalyzes it and give the first and/or second digit of its EC number, as indicated. (12 pts - 3 ea.) a) Isan → COASH + HO class: EC b) ATP AMAT hesreot + COASH class: EC ~ +10 lingen Ho class: EC MASH+ it is a mere class: EC
5. For each enzyme-catalyzes reaction below, state the specific class of enzyme that catalyzes it and give the first and/or second digit of its EC number, as indicated. (12 pts - 3 ea.) a) or Ascan onore → CASH + class: EC b) ATP AMP+R olstot + COASH class: EC c) of class: EC is met mens de class: EC-
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