Which of the following triggers apoptosis?
a. Fas ligand
b. NGF
c. TNF-alpha
d. Fas ligand and TNF-alpha
e. Capase 8
Please find the answer below:
Answer: d. Fas ligand and TNF-alpha
Explanation: Both TNF-alpha (Tumor Necrosis Factor-alpha) and the Fas ligand are considered as pro-apoptotic molecules. They are also responsible for cytokine and Chemokine production and expressed as inflammatory cells. It has been observed in recent studies that Fas ligand actually exerts more apoptotic effect and inflammation when compared to TNF-alpha. NGF (Nerve Growth Factor) is responsible for the growth, proliferation, and maintenance of neurons.
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