Which of the following adaptor proteins activate the NF- B pathway? A. MyD88 B. IKK-alpha C....
Which of the following adaptor proteins activate the NF- B pathway?
A. MyD88
B. IKK-alpha
C. Calmodulin
D. IL-2 receptor
E. IRF
Homework Answers
Answer. B. IKK-alpha.
When the IKKb is activated, it is shown to play a role in the phosphorylation of IkB. The IkB, upon phosphorylated, gets ubiquitinated and this becomes a marking for its degradation by proteases. This, then further releases NF-κB from the IkB-containing complex. Once the NF-κB gets released, the nuclear localization signal gets unmasked.
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Which of the following adaptor proteins activate the NF- B
pathway?
A. MyD88
B. IKK-alpha
C....
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