Question

NF-kappa B (NFKB) proteins are transcription factors that control the expression of genes involved in cellular processes such as proliferation, differentiation inflammation, and apoptosis. Dysfunction within the NFkB pathway can trigger indefinite cell proliferation and cell survival leading to the development of tumors. Stimul OS NIYA W IDTNOM IMAM IMENOVE 1. Explain how NFKB proteins are activated to promote cell survival. 2. How would a cell evade apoptosis if an IB Inhibitor of kappa B) protein could no longer bind to NFB

Answer 1

Provided image is not clear enough, But as I know about NfkB signaling here sharing some information hope u will get through it.

1. Two signaling pathways process to the activation of NF-κB,namely canonical pathway and the non-canonical pathway.

a. CANNONICAL PATHWAY

NF-κB dimers are activated by IKK-( inhibitor of kappa B kinase) mediated phosphorylation of IκB( inhibitor of kappa B).

As IkB get phosphorylation it undergoes proteosomal degredation.

Degredation of IkB lead to formation of the active NF-κB (p50 & p65) transcription factor subunits to translocate to the nucleus and induce target gene expression.

b. NON CANNONICAL PATHWAY

IKKα complex phosphorylates p100 leading to the proteosomal degradation of p100 and liberation of the p52/RelB as active heterodimer.

This dimer further procced to nucleus for target gene expression