Question

1)Angie has had many viral infections in her life. She has no problem with extracellular, bacterial infections. The doctor wants to run lots of screenings to determine if she has a deficiency in a protein needed to process these types of infections..What should they test for?

a)TLR2

b)Rig like receptor

c)NFkB

d)MyD88

2) Fill in the blank

___ bound by receptors on NK cells and Macrophages

____macrophage cells that are activated and secreted by dendetric cells

____job is the recruitment of necleophils

Answer 1

1)Angie has had many viral infections in her life. She has no problem with extracellular, bacterial infections. The doctor wants to run lots of screenings to determine if she has a deficiency in a protein needed to process these types of infections..What should they test for?

b) Rig like receptor.

Note: RIG-I (retinoic acid-inducible gene I) is a RIG like receptor dsRNA helicase enzyme which is encoded (in humans) by theb gene known as DDX58. The function of RIG-I i.e. a pattern recognition receptor that is sensor for viruses such as influenza A, Sendai virus, and flavivirus etc. Certain retroviruses like HIV-1 encode a protease enzyme that directs RIG-I to produce  lysosome for the degradation, and thereby evade RIG-I mediated signaling. RIG-I typically recognizes short (< 4000 nt) 5′ triphosphate uncapped double stranded or single stranded RNA molecule.RIG-I is also able to detect non-self 5′-triphosphorylated dsRNA transcribed from the AT-rich dsDNA by DNA-dependent RNA polymerase II.

2) Fill in the blank:

a) CD69 bound by receptors on NK cells and Macrophages.

b) M2 Macrophage cells that are activated and secreted by Dendetric cells.

c) Bone marrow job is the recruitment of Neutrophils.