Topic: Psychopharmacology . Why are Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) contraindicated to use with MAOIs?
Topic: Psychopharmacology .
Why are Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) contraindicated to use with MAOIs?
Homework Answers
SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors) are contraindicated in patients taking MAOIs (monoamine oxidase inhibitors) due to the increased risk of serotonin syndrome which can cause adverse effects or even death. Most commonly, serotonin syndrome occurs due to complex drug interaction between two serotonergic drugs (SNRIs and MAOIs) which have different mechanism of action. Symptoms include anxiety, agitation,tremors, hypertension, hyperthermia, diarrhea, vomiting etc. Combination of the two drugs result in excess secretion of serotonin in the central nervous system and symptoms can be observed after a day or two of extra serotonin secretion.
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Topic: Psychopharmacology .
Why are Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
contraindicated to use with MAOIs?
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