Question

How do antidepressants, such as MAOIs and selective serotonin reuptake inhibitors work? Why might an MAOI work for one person and a selective serotonin reuptake inhibitor work for another?

Answer 1

Selective serotonin reuptake inhibitors increases the level of serotonin transmitter, it do not significantly affect the level of norepinephrine in the brain. While MAOIs inhibits an enzyme called monoamine oxidase which is responsible for degrading norepinephrine, serotonin and dopamine and increases the level of norepinephrine, dopamine and serotonin transmitters in the brain.

As we know, serotonin is also known as happy chemical because it contributes in happiness and well-being. It's low level is been linked to depression and it plays an important role in maintaining mood balance.

Also, MAOIs are typically more potent than SSRIs because they affect more neurotransmitters , therefore MAOIs may work for one person and SSRIs for another.