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In muscle at rest, stimulation of the phosphatase that activates PDH is accomplished by ? Insulin...

  1. In muscle at rest, stimulation of the phosphatase that activates PDH is accomplished by ?
    1. Insulin
    2. Epinephrine
    3. PFK-2
    4. Citrate
    5. Ca2+
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Answer #1

Answer: Pyruvate dehydrogenase (PDH) is an enzyme that catalyze important step in cellular respiration. It is part of pyruvate dehydrogenase complex that convert pyruvate to acetyl CoA. PDH is regulated by PDH kinase and phosphatase. PDH kinase phosphorylates the PDH and inactivate the enzyme. Phosphatase removes the phosphate from inactive PDH and converts it to active form. Insulin and Ca2+ stimulate the phosphatase. In resting condition, insulin stimulates the phosphatase that activates PDH. In non-resting condition such during exercise and physical activity, Ca2+ activates the phosphatase. Hence, option a is the correct answer and option e is incorrect. Epinephrine, PFK-2 and citrate does not stimulate phosphatase. Hence, options b, c and d are incorrect.

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