Which of the following pertains to furanocoumarins produced by members of the Umbelliferae (like wild parsnip). Choose all that apply.
**I know B,C, and D are correct, but I am not sure/confused about whether or not A or E are also correct**
a. They are nervous system disruptors
b. Phototoxic - active only after irradiation by UV wavelengths present in sunlight
c. They are phenolics
d. They produce a nasty contact dermatitis
e. Can interfere with RNA production and therefore inhibit protein synthesis
Answer) B, C and D
Furanocoumarins are polyphenol produced by various types of plants, which are responsible for phototoxic reaction in human.
The furanocoumarins can react with nucleobases in DNA in the presence of UV A radiation, which leads to the formation of interstrand cross-links in thymine residues of DNA which leads to the dermatitis (photocontact dermatitis and cancer in skin). It mainly affect the DNA replication.
Which of the following pertains to furanocoumarins produced by members of the Umbelliferae (like wild parsnip)....
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