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1. What triggers the opening of each of the different channels: ligand-gated K+ channels, ligand-gated Na+...

1. What triggers the opening of each of the different channels: ligand-gated K+ channels, ligand-gated Na+ channels, ligand-gated Cl- channels, voltage-gated Na+ channels, voltage-gated K+ channels, voltage-gated Ca2+ channels.

2. What happens to membrane potential in the immediate area where the channel is located when the channel opens and ions flow through?

3. Since graded and action potentials happen in different locations on the neuron, explain what has to happen to link these different events together.

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  1. As soon as the neurotransmitter binds to the sodium channels (ligand gated) the channels open and lead to influx of the sodium ions. As, the depolarisation progresses, the voltage gated sodium channels receive a voltage specific threshold opening and open to produce more influx of sodium inside the cell membrane. There is presence of resting type of potassium channels which are always open. The ligand gated chloride channels open in response to a inhibitory neurotransmitter leading to chloride movement to prevent transmission of stimulus. As the stimulus progresses, the potassium channels at the end of depolarisation start opening due to changing voltage to start the process of re-polarisation. The voltage gated calcium channels work in a similar fashion as voltage gated sodium channels.
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