A drug that binds to target protein, A, with a dissociation constant of 1 nM. The...
A drug that binds to target protein, A, with a dissociation constant of 1 nM. The interaction between the drug and protein A is critical for treatment of a disease. The drug also binds toanother protein, B, with a dissociation constant of 1 μM; and that this unintended interaction has undesirable side effects. How do we determine a concentration at which to deliver the drug so that protein A is essentially shut down by the drug, while protein B is essentially unaffected? (show your strategy, calculations and conclusion).
Homework Answers
Request Answer!
We need at least 10 more requests to produce the answer.
0 / 10 have requested this problem solution
The more requests, the faster the answer.
Add Answer to:
A drug that binds to target protein, A, with a dissociation
constant of 1 nM. The...
Drug Miracurol (molecular weight 540 daltons) binds to a key oncogenic proteins, Malevolin, with a dissociation constant...
Drug Miracurol (molecular weight 540 daltons) binds to a key oncogenic proteins, Malevolin, with a dissociation constant of 0.1nM. A.what is the standard free energy change of the binding reaction between Miracurol and Malevolin at a temperature of 37C. (R=8.314Jmol-1K-1) B. what mass of Miracurol should be administered to a patient with a blood volume of 5.5L such that the final concentration of Miracurol in the patient's blood is enough to bind and inhibit at least 90% of Malevolin molecules?...
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent...
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCT) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI Species able to form that NCI Parameters affecting the NCI ions; charged species dipole-dipole any hydrogen bond strength and orientation of dipole polarizability, size: molecular weight species with permanent dipoles (C=0, etc.) H bonded to N, O, or F and a dielectric...
A drug D binds to a protein P with binding constant K1 = 1.58x10^6 at temperature...
A drug D binds to a protein P with binding constant K1 = 1.58x10^6 at temperature T1 = 298 K and with binding constant K2 = 1x10^6 at temperature T1 = 330 K. Determine how the extent of the binding of the drug θ changes if the analytical concentration of the drug [D]0 = 50 pM is held constant as the temperature is raised from 273 K to 373 K. You can assume that the temperature dependence of the binding...
Similar to the lecture, our example is a drug molecule D and a drug target enzyme...
Similar to the lecture, our example is a drug molecule D and a drug target enzyme E. The drug target enzyme E is commonly found in concentrations [E]tot of 250 nM, i.e. 2.5 x 10-7 mol/l. The drug D binds to E to form the complex ED with a dissociation constant of KD = 1.30 µM (i.e. 1.30 x 10-6). The dissociation constant has been determined at room temperature, i.e. for T = 298.15 K. 1. In order to estimate...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
explain 1 or 2 molecular details in how epigenetics may allow melanoma cells to outsmart BRAF inhibitors **This is for a genetics course Seope: This science commentary claims that epigeneties pl...
explain 1 or 2 molecular details in how epigenetics may allow
melanoma cells to outsmart BRAF inhibitors
**This is for a genetics course
Seope: This science commentary claims that epigeneties plays a role in cancer cells becoming therapy-resistant. The language used is generalized for the non-scientist and does not include any molecular details, such as methylation of a specific nucleotide in an allele or modification of a specific histone tail amino acid. Your task (individually or in a group of...
1. A calorie is a measure of the energy content of food. a. True b. False...
1. A calorie is a measure of the energy content of food. a. True b. False 2. Which chemical in the alcohol metabolic pathway is most toxic? a. ethanol b. acetaldehyde c. acetic acid d. none are toxic e. all are equally toxic 3. Which of the following are risks of long term regular use of alcohol. a. Increased cancer rates. b. Infertility and impotence. c. Diabetes. d. Liver disease. e. All of the above. 4. An amino acid is...
1. Describe the functions of the following reagents in extraction of DNA from corn meal: proteina...
1. Describe the functions of the following reagents in extraction of DNA from corn meal: proteinase K; guanidine HCI; SDS 2. Why is the ratio of the OD at 260 and 280 nm used to estimate DNA purity? 3. In one paragraph, summarize basic principles of PCR technique in your own words. List all the reagents you will need to perform a PCR experiment. Does this method tell you what genetic modifications were made? If yes, describe how you can...
Show instructions Questions 1-60 of 60 | Page 1 of 1 Question 1 Which statement by...
Show instructions Questions 1-60 of 60 | Page 1 of 1 Question 1 Which statement by a patient receiving high-dose melphalan indicates an understanding of the teaching O a "Blood counts are not routinely monitored during therapy. 9 b "tis important to take the tablet with food. Owill put honey in my tea daily. O d will suck on ice chips while the drug is being administered Question2 Prior to beginning treatment with daunorubicin, the patient should inform the nurse...
What are the instruments that have been utilized for the review article discussions? ` 1. Introduction...
What are the instruments that have been utilized for the
review article discussions?
`
1. Introduction In recent years, nanoclays have been the object of particular interest for many scientists and researchers in chemistry, physics, engineering and biology due to their excellent properties as well as their sustain- ability [1-3]. For instance, they represent the starting point to the de velopment of smart materials for drug delivery (4-9), food packaging [10-12), environmental remediation and wastewater treatment [13], cultural heritage [14–17and...
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCT) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI Species able to form that NCI Parameters affecting the NCI ions; charged species dipole-dipole any hydrogen bond strength and orientation of dipole polarizability, size: molecular weight species with permanent dipoles (C=0, etc.) H bonded to N, O, or F and a dielectric...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
explain 1 or 2 molecular details in how epigenetics may allow
melanoma cells to outsmart BRAF inhibitors
**This is for a genetics course
Seope: This science commentary claims that epigeneties plays a role in cancer cells becoming therapy-resistant. The language used is generalized for the non-scientist and does not include any molecular details, such as methylation of a specific nucleotide in an allele or modification of a specific histone tail amino acid. Your task (individually or in a group of...
1. Describe the functions of the following reagents in extraction of DNA from corn meal: proteinase K; guanidine HCI; SDS 2. Why is the ratio of the OD at 260 and 280 nm used to estimate DNA purity? 3. In one paragraph, summarize basic principles of PCR technique in your own words. List all the reagents you will need to perform a PCR experiment. Does this method tell you what genetic modifications were made? If yes, describe how you can...
Show instructions Questions 1-60 of 60 | Page 1 of 1 Question 1 Which statement by a patient receiving high-dose melphalan indicates an understanding of the teaching O a "Blood counts are not routinely monitored during therapy. 9 b "tis important to take the tablet with food. Owill put honey in my tea daily. O d will suck on ice chips while the drug is being administered Question2 Prior to beginning treatment with daunorubicin, the patient should inform the nurse...
What are the instruments that have been utilized for the
review article discussions?
`
1. Introduction In recent years, nanoclays have been the object of particular interest for many scientists and researchers in chemistry, physics, engineering and biology due to their excellent properties as well as their sustain- ability [1-3]. For instance, they represent the starting point to the de velopment of smart materials for drug delivery (4-9), food packaging [10-12), environmental remediation and wastewater treatment [13], cultural heritage [14–17and...
Most questions answered within 3 hours.
-
Important Information to answer the question:
Scale Solar Power Energy
The average price of a 4KW...
asked 27 minutes ago -
Lowell Corp. sells $100,000 of bonds to private investors. The
bonds are due in five years,...
asked 1 hour ago -
3) Do you believe that Disney’s
acquisition-based growth strategy is sustainable?
4) Which competencies support this...
asked 2 hours ago -
Rank the following three stocks by their total risk level highest
to lowest night writer has...
asked 2 hours ago -
A local
electronic company primarily manufactures four highly technical
telecommunication products. Each product must be processed...
asked 3 hours ago -
•Describe the basic structure of collagen monomers •Explain how
amino acid composition of collagen contributes to...
asked 5 hours ago -
Compute the sample correlation coefficient
r for each of the following data sets.
(Use 3 decimal...
asked 5 hours ago -
5a. What are the advantages and disadvantages of Proxy ARP?
b. What is the TTL field...
asked 5 hours ago -
An ice cube (density = 900[kg/m3]) with a side length of
2.54[cm] is held by a...
asked 7 hours ago -
would you say that leaders in the international context are born
or made? That is, can...
asked 7 hours ago -
Instructions
Read the Digital Trends article "Solid state drives are speedier
than hard disk drives. Are...
asked 7 hours ago -
A multiple-choice test consists of 29 questions with possible
answers of a, b, c, d. Estimate...
asked 7 hours ago