Question

An activator that does not have an activating domain may require a activating domain. (0.5 point) 5. with an 6. Boundary elements in a chromosome prevent chromatin modifications from or spreading from one area to another, thus preventing activation or repression of genes. (0.5 point) 7. SW/SNF is a type offound in yeast. (0.5 point)

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Answer 1

5 ) An activator that does not have an activating domain may require a basal apparatus with an activating domain.

Activating domain are independent and are connected in a way that allows the activating domain to interact with basal apparatus.

Activating domain works by making protein - protein contacts with general transcription factors that provide assembly of the basal apparatus contact with basal apparatus may be made with any of the several basal factors but typically occurs with TFIID, TFIIB or TFIIA.

6) Boundary elements or chromatin insulators in a chromosome prevent chromatin modifications from spreading one area to another, thus preventing activation or repression of genes.

Insulator function suggest a role for boundary elements in determining transcriptional identity of chromatin and in organising chromatin in to structural compartments with in the nucleus .

7) SWI/ SNF is a type of nucleosome remodeling complexes found in yeasts.

The SwI/SNF family of chromatin remodeling complexes was initially discovered in yeast by two independent screenings aimed at identifying mutations in genes that affect the matingtype switching (SWI) and sucrose fermentation pathway.