Question

1. A clinical trial is planned to compare an experimental medication designed to lower blood pressure to a placebo. Before starting the trial, a pilot study is conducted involving 7 participants. The objective of the study is to assess how systolic blood pressure changes over time untreated. Systolic blood pressures are measured at baseline and again 4 weeks later. Is there a statistically significant difference in blood pressures over time? Run the test at a 5% level of significance.

Baseline           120      145      130      160      152      143      126     

4 Weeks           122      142      135      158      155      140      130     

            Difference        -2         3          -5         2          -3         3          -4         S Differences = -6

            Difference²      4          9          25        4          9          9          16        S Differences² = 76

_

Xd= -6/7=-.086 sd= -3.44

Step 1.           Set up hypotheses and determine level of significance

           

Step 2.            Select the appropriate test statistic

                         

    

Step 3.            Set up decision rule

                       

Step 4.            Compute the test statistic

           

Step 5.            Conclusion

Answer 1

시D- naiVe Step tet statittet is sdep x o 97s2 45 ster Tesl stalitic Tert criteria 2.4s e rejet null hyeathetherwitie e fail t reject Ha to hypotheLL-- Decision --1 ve-fall t eject null conclus is ni- Them no-signittcantdit ference 15 blood Pre ssures ever tine. -