3. DNA polymerase I performs proofreading by requiring a higher concentration of the next dNTP following a mismatch, allowing time for unwinding of the nascent duplex and 3 5' exonuclease digestion. 4. The DNA duplex of the genome is flexible enough to allow many values of T for a given duplex length and still retain biological activity. 5. Base tautomeric shifts during replicative DNA polymerization can be repaired by DNA polymerase proofreading or by mismatch repair.
Homework Answers
3)True statement-DNA polymerase use 3'---5' exonuclease activity to remove the incorrect added T base.
4)The statement is false because inorder to carry out biological functiona within the cell the DNA should be almost flexible
but do not allow many T Because then corresponding complementary base sequence changes which may result in change in
dna function.
5) The statement is false beacuse polymerase checks only mismatched pair and not base shifts.
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