Question

Effect of urine pH on delivery route: Weak organic acids and bases can reach the luminal fluid (the filtrate, the primary urine) either by glomerular filtration in Bowman's capsule or by secretion in the proximal tubule. In both cases, only the ionized form of the organic acid or base can be transferred into the filtrate. a. Therefore, the pH of the urine has a strong influence on how effectively a weak organic acid or base is transferred into the filtrate. Please calculate the proportion of ionization at normal (pH-6) and basic (pH-8) urine pH for the weak acid and base given below using the Henderson-Hasselbach equation. 6.0) Weak Acid (pka Weak Base (pKa 7.0) HAA NH2 -NH Normal urine, pH -6.0 Basic urine, pH-8.0

I need to know the % output when :

weak acid( pKa=6) is in pH of urine at 6 and pH or urine at 8.

Also the weak base (pKa 7) in pH of urine at 6 and pH or urine at 8.

Answer 1

Car weak base LL101 1000-90.90-火 1L 10-X 100.- pka-p 1-6 1011土10-1) 9.09 iot1

G-G 14 lo G loo 8-6 1O +102