Question

QUESTION 7 Quiescent cells are cells which are in Go stage of the cell cycle. What stimulus would be required for these Go cells to re-enter the cell cycle? What event(s) occur after stimulation? Hint: Your complete response should include genes being transcribed and the different factors associated with that process ▼T·-·-▼ TTT Arial 3 (12pt) ▼ QUESTION 8 Consider that same cells in GO. In order for these cells to divide normally. they would need to renter G1 and then go through s phase and then G2 phase. What would happen to the cells if these phases did not occur? What would be the outcome for the cells in that case?

Answer 1

answer 7: The activation of MAP kinases and protein kinase C mediated signal transduction induces the exit from G₀ and entry into G1 phase of cell cycle. T lymphocytes have been used as cell models for studying cell cycle progression. it has been reported that a committment point in blood T cells exist 3 to 5 h after CD3/CD28 stimulation which is involved in the regulation of transistion from G₀ to G1. this entry requires cdk 6/4- cyclin D, as inhibition of cdk 6/4- cyclin D by inhibitor protein P16^INK4A which is coupled to TAT in first 3 to 5 h, stopped entry of T cells into cell cycle. Transduction of cells with TAT- P16^INK4A >5 h stimulate progression of cell cycle into G1.

Answer 8: if cells remain in G0 phase they will never be able to divide and therefore the cells will not grow and proliferate.