The (magnitude/specificity) of a drug effect is related to the effective concentration of the drug present at the recept...
The (magnitude/specificity) of a drug effect is related to the effective concentration of the drug present at the receptor. which is correct?
Homework Answers
The specificity is the right answer as it is also called efficacy which refers to the intrinsic activity of the drug. It is the ability of a drug to elicit a response when it binds to the receptor.
The magnitude is where the dose administered or the steady state of the average concentration of the drug effect.
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The (magnitude/specificity) of a drug effect is related to the effective concentration of the drug present at the recept...
1. How much of a drug is actually available to produce an effect at the receptor...
1. How much of a drug is actually available to produce an effect at the receptor is known as its (bioavailability/affinity). Which is correct?
6. A tetracycline repressor (TetR) protein, which is present in E. coli at 10^–8 M concentration,...
6. A tetracycline repressor (TetR) protein, which is present in E. coli at 10^–8 M concentration, binds to the tetO site with a KD of 10^–10M in the absence of the drug tetracycline and a KD of 10^–6M in the presence of tetracycline. There is one tetO site in the E. coli genome, giving a concentration of 10^–9M per cell. There are 2×10^5 nonmatching sites per cell (a concentration of 5 × 10^–2M), to which TetR binds nonspecifically with a...
If a bacterial species is not susceptible to an antibacterial drug at the concentration present in...
If a bacterial species is not susceptible to an antibacterial drug at the concentration present in a particular disk, does that necessarily mean the species is completely resistant to the drug? Explain your answer
Often, the effect of a drug gradually diminishes when it is given continuously or repeatedly. Desensitization...
Often, the effect of a drug gradually diminishes when it is given continuously or repeatedly. Desensitization and tachyphylaxis are synonymous terms used to describe this phenomenon. Desensitization is a general issue with extended treatment with GPCR agonists as phosphorylation of the receptor interferes with its ability to activate second messenger cascades, although it can still bind the agonist molecule. Which of the following would likely be true for an agonist drug binding to a receptor that has become desensitized over...
1. (Magnitude/specificity) is the property of receptors that allows them to differentiate among similar drugs and...
1. (Magnitude/specificity) is the property of receptors that allows them to differentiate among similar drugs and bind only to those with the critical features. Which is correct?
It is related to the maximum effect a drug can attain Affinity Solubility Efficacy Potency
It is related to the maximum effect a drug can attain Affinity Solubility Efficacy Potency
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of .........................
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of ...................... is important for the drug that is excreted unchanged. 10. pka is the ................. at which 50% of drugs present in an ionised form. 17. Renal excretion has 3 processes namely ......... .................... and ............... 18. The study of what the body does to the drug is known as ....... 19. Enzyme inducers .................. the effect of other drugs but the enzyme inhibitors ......
Match the following terminologies related to antimicrobial drugs with their appropriate descriptions. minimal inhibitory concentration (MIC)...
Match the following terminologies related to antimicrobial drugs with their appropriate descriptions. minimal inhibitory concentration (MIC) This term is used to describe compounds that cause greater harm to microbes than to the human host. narrow-spectrum drug This term is used to describe the lowest concentration of a drug effective at preventing growth of particular microbes. selective toxicity This term is used to describe drugs that are effective against only a limited variety of microbes.
KB) You wish to determine the hormone-binding specificity of a newly identified membrane receptor. Three different...
KB) You wish to determine the hormone-binding specificity of a newly identified membrane receptor. Three different hormones, X, Y, and Z, were mixed with the receptor in separate experiments, and the percentage of binding capacity of the receptor was determined as a function of hormone concentration, as shown in graph A. 100 X BO 60 60 40 20 20 10 10 10 10 Hormone concentration (M) 10" 10" 10" 10° Hormone concentration (M) You next wish to determine whether the...
Concentration What does the graph above show? A dose-response curve for a competitive antagonist A drug-receptor...
Concentration What does the graph above show? A dose-response curve for a competitive antagonist A drug-receptor binding curve for a noncompetitive antagonist A dose-response curve for a partial agonist A drug-receptor binding curve for a full agonist % ligand binding O O
Often, the effect of a drug gradually diminishes when it is given continuously or repeatedly. Desensitization and tachyphylaxis are synonymous terms used to describe this phenomenon. Desensitization is a general issue with extended treatment with GPCR agonists as phosphorylation of the receptor interferes with its ability to activate second messenger cascades, although it can still bind the agonist molecule. Which of the following would likely be true for an agonist drug binding to a receptor that has become desensitized over...
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of ...................... is important for the drug that is excreted unchanged. 10. pka is the ................. at which 50% of drugs present in an ionised form. 17. Renal excretion has 3 processes namely ......... .................... and ............... 18. The study of what the body does to the drug is known as ....... 19. Enzyme inducers .................. the effect of other drugs but the enzyme inhibitors ......
Match the following terminologies related to antimicrobial drugs with their appropriate descriptions. minimal inhibitory concentration (MIC) This term is used to describe compounds that cause greater harm to microbes than to the human host. narrow-spectrum drug This term is used to describe the lowest concentration of a drug effective at preventing growth of particular microbes. selective toxicity This term is used to describe drugs that are effective against only a limited variety of microbes.
KB) You wish to determine the hormone-binding specificity of a newly identified membrane receptor. Three different hormones, X, Y, and Z, were mixed with the receptor in separate experiments, and the percentage of binding capacity of the receptor was determined as a function of hormone concentration, as shown in graph A. 100 X BO 60 60 40 20 20 10 10 10 10 Hormone concentration (M) 10" 10" 10" 10° Hormone concentration (M) You next wish to determine whether the...
Concentration What does the graph above show? A dose-response curve for a competitive antagonist A drug-receptor binding curve for a noncompetitive antagonist A dose-response curve for a partial agonist A drug-receptor binding curve for a full agonist % ligand binding O O
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