1. How much of a drug is actually available to produce an effect at the receptor...
1. How much of a drug is actually available to produce an effect at the receptor is known as its (bioavailability/affinity). Which is correct?
Homework Answers
Answer: The drug is actually available to produce an effect at the receptor is known as Bioavailability. It can be defined as the amount of the drug which enters the circulation and produces an active effect. Bioavailability of a drug depends upon properties of the dosage form, which depend partly on its design and manufacture, whereas affinity can be defined as a measure of how tightly a drug binds to a receptor.
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1. How much of a drug is actually available to produce an effect
at the receptor...
Often, the effect of a drug gradually diminishes when it is given continuously or repeatedly. Desensitization...
Often, the effect of a drug gradually diminishes when it is given continuously or repeatedly. Desensitization and tachyphylaxis are synonymous terms used to describe this phenomenon. Desensitization is a general issue with extended treatment with GPCR agonists as phosphorylation of the receptor interferes with its ability to activate second messenger cascades, although it can still bind the agonist molecule. Which of the following would likely be true for an agonist drug binding to a receptor that has become desensitized over...
The (magnitude/specificity) of a drug effect is related to the effective concentration of the drug present at the recept...
The (magnitude/specificity) of a drug effect is related to the effective concentration of the drug present at the receptor. which is correct?
A The drug being studied is usually a small organic molecule drug design reliles on computer mode...
A The drug being studied is usually a small organic molecule drug design reliles on computer modeling techniques based on the knowledge of the thre dimensional structure of the enzyme or protein biomolecular target Physiochemical C. properties, such as log Poe, of the candidate drug molecule are never an important In the most basic sense, drug design involves the design and charge to the blomolecular target with which they interact and therefore will bind to it D. of molecules that...
the primary factor determining the length of time for a drug to produce its' effect is...
the primary factor determining the length of time for a drug to produce its' effect is a) absorption b) distribution c) Métabolisme d) Excretion
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
15. Match each term with the best definition: Terms: 1) Lead Compound 2) Enteral Administration 3)...
15. Match each term with the best definition: Terms: 1) Lead Compound 2) Enteral Administration 3) Drug Regimen 4) Prodrug 5) Pharmacophore 6) Excipient 7) Pharmacokinetic Phase 8) Pharmodynamic Phase 9) Structure Activity Relationship 10) Bioavailability Definition: A) A structure known to be biologically active. MATCHES WITH B) A systematic approach to drug discovery. MATCHES WITH C) The minimal structure of a ligand that binds the receptor. MATCHES WITH D) A systematic plan to effect or maintain health. MATCHES WITH...
Discuss the pharmacokinetics of children 1 year old or older. Discuss reasons pediatric patients are subject...
Discuss the pharmacokinetics of children 1 year old or older. Discuss reasons pediatric patients are subject to adverse drug reactions when drug levels rise too high. Discuss dosage determination, noting that pediatric doses have been established for some drugs but not for others and, therefore, for drugs that do not have established pediatric doses, the doses can be extrapolated from adult doses. Discuss the appropriate steps in determining exposure to teratogens. Discuss drug therapy during breast-feeding and the potential risks...
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of .........................
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of ...................... is important for the drug that is excreted unchanged. 10. pka is the ................. at which 50% of drugs present in an ionised form. 17. Renal excretion has 3 processes namely ......... .................... and ............... 18. The study of what the body does to the drug is known as ....... 19. Enzyme inducers .................. the effect of other drugs but the enzyme inhibitors ......
A new drug has recently become available which, it is claimed, will relieve the symptoms of...
A new drug has recently become available which, it is claimed, will relieve the symptoms of restless leg syndrome (RLS). A physician gave this drug to 30 patients who were known to suffer from RLS. Among these patients, 24 reported they experienced some significant relief, though 6 reported no change. What can be concluded from this information? A) This study has demonstrated the effectiveness of this new drug against the symptoms of RLS. B) Nothing much can be concluded since...
1. (Efficacy/potency) refers to the degree to which a drug is able to produce maximal effects....
1. (Efficacy/potency) refers to the degree to which a drug is able to produce maximal effects. Which is correct?
Often, the effect of a drug gradually diminishes when it is given continuously or repeatedly. Desensitization and tachyphylaxis are synonymous terms used to describe this phenomenon. Desensitization is a general issue with extended treatment with GPCR agonists as phosphorylation of the receptor interferes with its ability to activate second messenger cascades, although it can still bind the agonist molecule. Which of the following would likely be true for an agonist drug binding to a receptor that has become desensitized over...
A The drug being studied is usually a small organic molecule drug design reliles on computer modeling techniques based on the knowledge of the thre dimensional structure of the enzyme or protein biomolecular target Physiochemical C. properties, such as log Poe, of the candidate drug molecule are never an important In the most basic sense, drug design involves the design and charge to the blomolecular target with which they interact and therefore will bind to it D. of molecules that...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
15. Match each term with the best definition: Terms: 1) Lead Compound 2) Enteral Administration 3) Drug Regimen 4) Prodrug 5) Pharmacophore 6) Excipient 7) Pharmacokinetic Phase 8) Pharmodynamic Phase 9) Structure Activity Relationship 10) Bioavailability Definition: A) A structure known to be biologically active. MATCHES WITH B) A systematic approach to drug discovery. MATCHES WITH C) The minimal structure of a ligand that binds the receptor. MATCHES WITH D) A systematic plan to effect or maintain health. MATCHES WITH...
13. Drug metabolizing enzymes are present in ...... but mainly in ..................... 13. Function of ...................... is important for the drug that is excreted unchanged. 10. pka is the ................. at which 50% of drugs present in an ionised form. 17. Renal excretion has 3 processes namely ......... .................... and ............... 18. The study of what the body does to the drug is known as ....... 19. Enzyme inducers .................. the effect of other drugs but the enzyme inhibitors ......
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