Homework Answers
Answer.D.the graphs shows the full concentration of antagonist drug binding with a receptor.
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Concentration What does the graph above show? A dose-response curve for a competitive antagonist A drug-receptor...
What is a drug receptor? What are the major types and how do they differ? What’s...
What is a drug receptor? What are the major types and how do they differ? What’s the receptor phenomena of upregulation and downregulation? What are the major components of dose-response function and what do they represent? Define the term full, partial, and inverse agonist; allosteric drug; and antagonist.
Select one compound (drug or toxicant) that targets one of the three receptor types(G-protein coupled receptor pathway, A receptor tyrosine kinase pathway, An ion channel pathway ) and discuss the fol...
Select one compound (drug or toxicant) that targets one of the three receptor types(G-protein coupled receptor pathway, A receptor tyrosine kinase pathway, An ion channel pathway ) and discuss the following for the selected compound: The name of the receptor involved The type of ligand that the drug or toxicant presents: Agonist, antagonist Are there natural ligands that interact with the receptor? If so explain the interaction. Provide a brief explanation of the mechanism of the cellular response upon ligand...
This is a second time I ask this question, as the first time I didn't get...
This is a second time I ask this question, as the first time I didn't get proper answer. I need the exact option from the listed above. Thanks Diphenhydramine (Benadryl®) is an antihistamine. This drug is given to the patient approximately 30 minutes before infusion of the T cells in order to treat any immune reactions that may occur as a result of the infusion. Histamine acts as a full agonist at its receptor, the HA receptor, as part of...
3. A quantal response: A. is characterized by a flat-shaped dose-response curve B. provides information about...
3. A quantal response: A. is characterized by a flat-shaped dose-response curve B. provides information about the variations in insensitivity to a drug within the studied population C. is characterized by the bulk of patients responding at a high dose, as opposed to intermediate or low dosages D. is related to both the drug concentration and receptor occupancy E. B & D
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Drugs A, B, and C are Dopamine Receptor Agonists used to treat Parkinson’s disease. Drug A has...
Drugs A, B, and C are Dopamine Receptor Agonists used to treat Parkinson’s disease. Drug A has an EC50of 30 mg/mL, Drug B has an EC50of 20 µg/mL, and Drug C has an EC50of 40 g/mL. Drug C is 50% less efficacious than Drugs A or B. Graph these drugs on a semi-log graded dose-response curve (all on one graph and label the axis). Can you determine the Kdof each of these drugs from the data (tell me why or why not too: HINT-look...
Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in...
Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in the management of complex partial seizures and simple or complex absence seizures. In early preclinical development, they need to determine the affinity, efficacy, and potency for each drug. The results from the drug-receptor binding curves and the dose-response curves show that: 1) for Drug A it has a low Kd value, a high Emax, and a high EC50, and in comparison 2) Drug B...
The generic name of beta 1 and beta 2 receptor antagonist share what common suffix? -azole...
The generic name of beta 1 and beta 2 receptor antagonist share what common suffix? -azole -lol -osin -sartan 0.5 points QUESTION 35 Which laboratory result for international normalized ration (INR), if identified in a patient with atrial fibrillation who is receiving warfarin (coumadin), would indicate that the warfarin therapy has achieved the desired effect? INR 1 INR 3 INR 5 INR 7 0.5 points QUESTION 36 A patient who has overdosed on methadone, an opiate, is brought...
What does it mean if a beta blocker is classified as cardioselective? It's selective for what receptor? What is the...
What does it mean if a beta blocker is classified as cardioselective? It's selective for what receptor? What is the overall effect of adreneric drugs on the heart and cardiovascular system? What is the overall effect of adrenergic drugs on the eye? What is the overall effect of adrenergic drugs on bronchial smooth muscle? What is the overall effect of adrenergic drugs on the urinary bladder? What is an important potential toxicity of atropine and other muscarinic antagonists in infants...
9. Given Firm 1's best-response curve, show how Firm 2's best-response curve shifts on a graph...
9. Given Firm 1's best-response curve, show how Firm 2's best-response curve shifts on a graph if its marginal cost changes from m to m+x. Show how the Nash-Cournot equilibrium changes as Firm 2's marginal cost increases. O O Initially, assume the marginal cost for both firms is m, resulting in the best-response functions shown in the graph. 3 Now assume that the second firm's marginal cost of production changes from m to m + x 1.) Using the line...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in the management of complex partial seizures and simple or complex absence seizures. In early preclinical development, they need to determine the affinity, efficacy, and potency for each drug. The results from the drug-receptor binding curves and the dose-response curves show that: 1) for Drug A it has a low Kd value, a high Emax, and a high EC50, and in comparison 2) Drug B...
What does it mean if a beta blocker is classified as cardioselective? It's selective for what receptor? What is the overall effect of adreneric drugs on the heart and cardiovascular system? What is the overall effect of adrenergic drugs on the eye? What is the overall effect of adrenergic drugs on bronchial smooth muscle? What is the overall effect of adrenergic drugs on the urinary bladder? What is an important potential toxicity of atropine and other muscarinic antagonists in infants...
9. Given Firm 1's best-response curve, show how Firm 2's best-response curve shifts on a graph if its marginal cost changes from m to m+x. Show how the Nash-Cournot equilibrium changes as Firm 2's marginal cost increases. O O Initially, assume the marginal cost for both firms is m, resulting in the best-response functions shown in the graph. 3 Now assume that the second firm's marginal cost of production changes from m to m + x 1.) Using the line...
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