Question

Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in the management of complex partial seizures and simple or complex absence seizures. In early preclinical development, they need to determine the affinity, efficacy, and potency for each drug. The results from the drug-receptor binding curves and the dose-response curves show that: 1) for Drug A it has a low Kd value, a high Emax, and a high EC50, and in comparison 2) Drug B has a higher Kd value, a lower Emax, and a lower EC50. Based on this information, the investigators can conclude that Drug A is efficacious than Drug B and _ has a higher affinity for the molecular target in question. o less; Drug B O more; Drug A O more; Drug B o less; Drug A

Answer 1

The logic says that the high Kd value indicates that there is requirement of high amount of drug to occupy 50% of receptors, thus it indicates a weak or low binding to the receptors.

Hence based on the logic and the abouve findings , since the drug A has low Kd value , hence it will have higher binding to the receptors.

So the DRug A is more efficacious than the drug B and drug A has higher affinity for the molecular targets in the question.

Consequently the option B is the correct answer.