Homework Answers
Drug A is more potent than the Drug B. The amount of higher of drug a EC50 of 3.7mg/l. more then drug b EC50 of 0.91mg/l.
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The potencies of two drugs that act on the same receptor are being compared. Both drugs...
Drugs A, B, and C are Dopamine Receptor Agonists used to treat Parkinson’s disease. Drug A has...
Drugs A, B, and C are Dopamine Receptor Agonists used to treat Parkinson’s disease. Drug A has an EC50of 30 mg/mL, Drug B has an EC50of 20 µg/mL, and Drug C has an EC50of 40 g/mL. Drug C is 50% less efficacious than Drugs A or B. Graph these drugs on a semi-log graded dose-response curve (all on one graph and label the axis). Can you determine the Kdof each of these drugs from the data (tell me why or why not too: HINT-look...
Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in...
Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in the management of complex partial seizures and simple or complex absence seizures. In early preclinical development, they need to determine the affinity, efficacy, and potency for each drug. The results from the drug-receptor binding curves and the dose-response curves show that: 1) for Drug A it has a low Kd value, a high Emax, and a high EC50, and in comparison 2) Drug B...
3. Two drugs are compared to see which of them is more likely to produce unpleasant side effects....
3. Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Each of 100 subjects is given the two drugs on different occasions. The results are tabulated below Nausea with drug B 38 10 No nausea with B Nausea with drug A No nausea with A 50 Let pij denote the probabilities that a patient has a response in the ijth cell. For instance p12 denotes the probability that a patient experiences nausea...
Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Ea...
Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Each of 100 subjects is given the two drugs on different occasions. The results are tabulated below Nausea with drug B 38 10 No nausea with B 50 Nausea with drug A No nausea with A Let pij denote the probabilities that a patient has a response in the ijth cell. For instance p12 denotes the probability that a patient experiences nausea with...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
3. Two drugs are compared to see which of them is more likely to produce unpleasant side effects....
Please donot copy from other answers
3. Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Each of 100 subjects is given the two drugs on different occasions. The results are tabulated below Nausea with No nausea Nausea with drug3wit Nausea with drug A No nausea with A 38 10 2 50 Let pij denote the probabilities that a patient has a response in the ijth ce. For instance p12 denotes the...
Two drugs are being used to treat a sickness. Studies have shown that the length of...
Two drugs are being used to treat a sickness. Studies have shown that the length of the sickness can be modeled by 2(x, y) = x2 + 6y2 – 12x – 42y + 2xy + 180 where x is the amount of Drug A and y is the amount of Drug B (both in hundreds of milligrams). What amounts of Drug A and Drug B would minimize the length of the sickness? Drug A hundred mg Drug B hundred mg
Discuss the pharmacokinetics of children 1 year old or older. Discuss reasons pediatric patients are subject...
Discuss the pharmacokinetics of children 1 year old or older. Discuss reasons pediatric patients are subject to adverse drug reactions when drug levels rise too high. Discuss dosage determination, noting that pediatric doses have been established for some drugs but not for others and, therefore, for drugs that do not have established pediatric doses, the doses can be extrapolated from adult doses. Discuss the appropriate steps in determining exposure to teratogens. Discuss drug therapy during breast-feeding and the potential risks...
cv response le Blists some receptor agonists & antagonists that could be used in treating the...
cv response
le Blists some receptor agonists & antagonists that could be used in treating the following clinical the drugs listed in this table are not necessarily the ones most often used to treat the conditions in the and may not represent the best treatment available However studying these drugs and their effects you better understand the relationship between the autonomic nervous system and the cardiovas Table B 96 AS odst o Drug Effects on Receptor Atenolol Beta: blocker Propranolol...
In female mice, both the glucocorticoid (cortisol) receptor and the estrogen receptor are expressed in liver...
In female mice, both the glucocorticoid (cortisol) receptor and the estrogen receptor are expressed in liver cells (hepatocytes). The control element to which the glucocorticoid receptor binds is a short-strip of DNA that can accommodate the binding of the glucocorticoid receptor dimer. This control element is called a glucocorticoid response element (GRE). It is located1000 bp downstream from the poly-A site for the PEPCK gene. When this gene is activated by cortisol, it helps the hepatocyte to release glucose into...
Two drugs (Drug A and Drug B) are being investigated for their effectiveness as anticonvulsants in the management of complex partial seizures and simple or complex absence seizures. In early preclinical development, they need to determine the affinity, efficacy, and potency for each drug. The results from the drug-receptor binding curves and the dose-response curves show that: 1) for Drug A it has a low Kd value, a high Emax, and a high EC50, and in comparison 2) Drug B...
3. Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Each of 100 subjects is given the two drugs on different occasions. The results are tabulated below Nausea with drug B 38 10 No nausea with B Nausea with drug A No nausea with A 50 Let pij denote the probabilities that a patient has a response in the ijth cell. For instance p12 denotes the probability that a patient experiences nausea...
Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Each of 100 subjects is given the two drugs on different occasions. The results are tabulated below Nausea with drug B 38 10 No nausea with B 50 Nausea with drug A No nausea with A Let pij denote the probabilities that a patient has a response in the ijth cell. For instance p12 denotes the probability that a patient experiences nausea with...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Please donot copy from other answers
3. Two drugs are compared to see which of them is more likely to produce unpleasant side effects. Each of 100 subjects is given the two drugs on different occasions. The results are tabulated below Nausea with No nausea Nausea with drug3wit Nausea with drug A No nausea with A 38 10 2 50 Let pij denote the probabilities that a patient has a response in the ijth ce. For instance p12 denotes the...
Two drugs are being used to treat a sickness. Studies have shown that the length of the sickness can be modeled by 2(x, y) = x2 + 6y2 – 12x – 42y + 2xy + 180 where x is the amount of Drug A and y is the amount of Drug B (both in hundreds of milligrams). What amounts of Drug A and Drug B would minimize the length of the sickness? Drug A hundred mg Drug B hundred mg
cv response
le Blists some receptor agonists & antagonists that could be used in treating the following clinical the drugs listed in this table are not necessarily the ones most often used to treat the conditions in the and may not represent the best treatment available However studying these drugs and their effects you better understand the relationship between the autonomic nervous system and the cardiovas Table B 96 AS odst o Drug Effects on Receptor Atenolol Beta: blocker Propranolol...
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