Question

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le Blists some receptor agonists & antagonists that could be used in treating the following clinical the drugs listed in this table are not necessarily the ones most often used to treat the conditions in the and may not represent the best treatment available However studying these drugs and their effects you better understand the relationship between the autonomic nervous system and the cardiovas Table B 96 AS odst o Drug Effects on Receptor Atenolol Beta: blocker Propranolol Beta, Beta2 receptor blocker Prazosin Alpha: receptor blocker Atropine ACh receptor blocker Phenylephrine Alpha agonist Dobutamine Beta agonist Betaz agonist Alpha, Alphaz, Beta: agonist Albuterol Norepinephrine Case 1: Richard Thompson is a 35-year-old male whose blo son is a 35-year-old male whose blood pressure was consistently tested at approximately Heenite following a low-Sodium diet, omitting alcohol, and beginning an exercise program. He 145/100 mmHg despite following a low-sodium diet, om hae na svmptoms related to this elevated blood pressure. He hae hier s elevated blood pressure. He has a history of asthma. A. Which of the receptor an Which of the receptor antagonists might be useful for treating his hypertension without worsening his asthma? Explain. Case2: June Johnson is a 55-year-old female substernal chest pain. On physical exam was 75 and her blood pressure was confirmed the diagnosis of a myocardial infarction is a 55-year-old female who was admitted to the hospital during two hours of crushing bin on physical examination she was pale and diaphoretic, in obvious distress. Her pulse her blood pressure was 75/40. An EKG showed ST elevations, and cardiac enzymes drawn If you were forced to use a drug to improve her blood pressure, which receptor agonist would be the most helpful for increasing her cardiac output without increasing afterload? Explain. c. Why wouldn't you want to increase afterload?

Answer 1

CASE 1

A. Prazosin and phenylephrine are group of drug given to patient with asthmatic conditions, because when treating with beta blockers, beta1 and ACE causes the blood vessels to open up, blocking beta receptors and respiratory passages, causes the airways to constrict and could be dangerous. ARBs, calcium channel blockers, diuretics are considered as safe drug for hypertension patient with asthma.

CASE 2

B. Dobutamine with positive inotropic and mild chronotropic effect reduces the afterload and increases cardiac output.

C. Afterload should not be increased because the patient has been diagnosed with myocardial infarction, increasing it the heart will need increased oxygen demand to meet the needs. Failure of it will lead to death/necrosis of heart muscles.