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How do protein channels distinguish charged ions for selective transport? particularly in reference to ionic radii, and...

How do protein channels distinguish charged ions for selective transport?

particularly in reference to ionic radii, and free energy of hydration.

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There are two classes of ionophoric proteins, Ion channels and ion transporters. The ion channels are narrow, water-filled tunnels that allow only ions of a certain size and/or charge to pass through. This characteristic is called selective permeability. The archetypal channel pore is just one or two atoms wide at its narrowest point and is selective for specific species of ion, such as sodium or potassium. They are distinguishable due to their high ionic flow rate and flowing according to electrochemical gradient. Free energy of hydration also plays important role in the selectivity of ions passing through the channel.

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