Question

2) State 10 concepts, clearly described/defined, that is difficult in "Pharmacokinetics".

YES DUMMY 10

Answer 1

Pharmacokinetics is defined as the study of the time course of drug absorbtion, distribution, metabolism & excretion. Clinical pharmacokinetics is the application of pharmacokineticpharmacokinetic principleprinciples to the safe & effective therapeutic management of drugs in an individual patient.

Factors affecting pharmacokinetics of drugs:

4 factors that will influence pharmacokinetic test:water solubility, fat soluble, dissociation degree & molecular wight.

Parameters :

Volume of distribution at steady - state, may also vary with changes in physiologic & pathologic conditions.

Absorption :

Absorption is the movement of a drug from its site of administration into blood. Most drugs are absorbed by passive absorption but some drugs need carrier mediated transport. Small molecules defuse than large molecules.

Distribution :

Distribution is the movement of drug throughout the body. Determined by the blood flow to the tissues, it is ability of the drug to enter the vasculature system & the ability ofvthe drug to enter the cell if required.

Blood brain barrier (BBB):

The capillaries in the CNS are different they have pores which are sealed by the connective tissue & hence only small molecules can cross the BBB & the substance than can cross over have to be very lipophilic in nature.

Bio transformation :

It is the process of transformation of the drug with in the body to make it more hydrophilic so that it can be excreted out from the body by the kidneys.

Excretion :

Removal of the substance from the body. Some drugs are either excreted out unchanged or some are excreted out as metabolites in the urine or bile.