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Active Learning Template Medication: Gentamycin.

Active Learning Template Medication: Gentamycin.
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Answer #1

#. Drug - Gentamycin

#. Drug Class

Antibacterial: aminoglycoside

#. Pregnancy Category

C

#. Therapeutic Uses

to treat serious infections caused by gram-negative organisms; to treat pelvic inflammatory disease; effective against MRSA infections

#. Mode of Action

inhibition of bacterial protein synthesis; bactericidal effect

#. Side Effects

anorexia, nausea, vomiting, rash, numbness, visual disturbances, tremors, tinnitus, pruritus, muscle cramps or weakness, photosensitivity

#. Adverse Reactions

oliguria, urticaria, palpitations, superinfection

life-threatening: ototoxicity, nephrotoxicity, thrombocytopenia, agranulocytosis, neuromuscular blockade, liver damage

#. Contraindications

hypersensitivity, severe renal disease, pregnancy, and breastfeeding

caution: renal disease, neuromuscular disorders (myasthenia gravis, parkinsonism), heart failure, older adults, neonates

#. Drug Interactions

increase risk of ototoxicity with loop diuretics, methoxyflurane; increase risk of nephrotoxicity with amphotericin B, polymyxin, cisplatin, furosemide, vancomycin

#. Lab Interactions

-increase BUN, serum AST, ALT, LDH, bilirubin, creatinine

-decrease serum potassium and magnesium

#. Pharmacokinetics

Absorption: IM, IV

Distribution: PB: UK

Metabolism: t1/2: 2 hrs

Excretion: unchanged in urine

#. Nursing interventions :-

- Assess the vitals of the patient

- Assess patients nutritional status

- Assess for hearing impairment

- Monitor LFT / RFT

- Check for side effects

- Educate patient about the side effects

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