Question

Please solve this problem in MATLAB.

Problem 3 In pharmacokinetics the area under the curve (AUC) in the plot of concentration vs time represents the total amount of drug absorbed by the body. This is a very useful metric when trying to determine whether two formulation release the same amount of drug to the body. For an intravenous drug delivery, the concentration as a function of time is given as: Ci(t) = Do.ive-kt, where Do.iv is the initial dose. For an oral administration of the drug the concentration Do,oral (e-kit e-k2t), where Do.oral is the initial dose. For a drug you is given by: Coral(t) k2-ki are studying, you are given that: Do.iv would produce the same AUC for both i.v. and oral administration of the drug over 10 hours? 1, k 1, k1 1, k2 = 2. What oral initial dose, Doral

Answer 1

`Hey,

Note: Brother in case of any queries, just comment in box I would be very happy to assist all your queries

clc
clear all
k1=1;
k2=2;
f=@(x) integral(@(t) exp(-t),0,10)-integral(@(t) x*(exp(-k1*t)-exp(-k2*t))/(k2-k1),0,10);
Doral=fzero(f,2)

MATLAB R2018a Search Documentation Log In HOME PLOTS APPS EDITOR PUBLISH VEW Insert fx Find Files Run Section Go To Compare Comment% New Open Sav Breakpoints Rur Run and eAdvance Run and Indent Print Find Advance Time EIL NAVIGATE EDIT BREAKPOINTS BUN C:Users PRADEEP KALRA Documents MATLAB Editor - CAUsers\PRADEEP KALRA Documents\MATLA B1saveee.m saveee.m bisectionmethodbypradeep.m SimpsonComp.m x falsepos.m xfindroots.m Xsecantbypradeep.m jacobi iter.m + Current Folder x Name mathlab clc mynewdir clear all New folder a1.m a2.m k2-2: f- (x) integral ( (t) exp -t),0,10)-integral (@ (t) Doral-fzero (f, 2) x* (exp (-klt)-exp (-k2 t) ) / (k2-kl),0,10); d m a5.m A1.dat A1.mat A3 dat A4.dat AS.dat Details Command Window New to MATLAB? See resources for Getting Started Workspace Name Value Doral Doral- 2.0001 (x)integral(@(t)exp. k1 k2 2.000090803982019 J>> Col 7 script In 6 ENG 2:17 AM O Type here to search 06/23/19

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