The C-terminal end of a protein extends into the aqueous environment surrounding the protein. The C-terminal amino acids are Gin, Asp, 2 Ser, and three nonpolar amino acids. Assuming that the ∆G° for the formation of a hydrogen bond is—3 kcal/mol and the ∆G° for removal of a hydrophobic group from water is—4 kcal/mol, calculate the ∆G° for folding the C-terminal end of the protein into the interior of the protein under the following conditions:
a. Each of the polar groups forms one intramolecular hydrogen bond
b. All but two of the polar groups form intramolecular hydrogen bonds
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