The gene controlling the Xg blood group alleles (Xg+ and Xg~) and the gene controlling a newly described form of inherited recessive muscle weakness called episodic muscle weakness (EMWX) (Ryan et al., 1999) are closely linked on the X chromosome in humans at position Xp22.3 (the tip of the short arm). A male with EMWX who is Xg-marries a woman who is Xg+, and they have eight daughters and one son, all of whom are normal for muscle function, the male being Xg+ and all the daughters being heterozygous at both the EMWX and Xg loci. Following is a table that lists three of the daughters with the phenotypes of their husbands and children.
| Husband’s Phenotype | Offspring’s Sex | Offspring’s Phenotype |
Daughter 1: | Xg+ | female | Xg+ |
|
| male | EMWX, Xg+ |
Daughter 2: | Xg– | male | Xg– |
|
| female | Xg+ |
|
| male | EMWX, Xg– |
Daughter 3: | Xg– | male | EMWX, Xg– |
|
| male | Xg+ |
|
| male | Xg– |
|
| male | EMWX, Xg+ |
|
| male | Xg– |
|
| male | EMWX, Xg– |
|
| female | Xg+ |
|
| female | Xg– |
|
| female | Xg+ |
(a) Create a pedigree that represents all data stated above and in the following table.
(b) For each of the offspring, indicate whether or not a crossover was required to produce the phenotypes that are given.
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