Problem

Solutions For An Introduction to Genetic Analysis Chapter 16 Problem 32P

Step-by-Step Solution

Solution 1

The deoxyribonucleic acid (DNA) mismatch repair technique involves recognition of wrong insertions, deletions, and mis-incorporation of bases that arise during replication and recombination.

The enzyme DNA polymerase has three major roles:

• Unwinding the DNA strand

• Replication of DNA

• Mismatch repair of DNA

The mismatch repair technique runs after the addition of nucleotides to the complementary stand. So, this technique follows the replication process but does not begin after the process. Hence, the option (b) is not correct.

The stalled replication fork initiates unwinding of DNA strand. It also activates replication process. Hence, the option (c) is not correct.

Mismatch repair pathway follows the replication process but is not coupled with transcription. Hence, the option (d) is not correct.

The mismatch repair technique is strand specific, which distinguishes template strand from leading strand. The DNA polymerase binds specifically to the leading strand and replaces the wrong bases based on the template strand.

The mismatch repair technique runs after the addition of nucleotides to the complementary stand. So, this technique follows the replication process but does not begin after the process. The proof reading activity of DNA polymerase helps to repair the mismatches.

Hence, the correct option is a.

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