Is lactate an allosteric effector of Mb?
Lactate, a metabolite produced under anaerobic conditions in muscle, lowers the affinity of myoglobin for O2. This effect is beneficial, because O2 dissociation from Mb under anaerobic conditions will provide the muscle with oxygen. Lactate binds to Mb at a site distinct from the O2- binding site at the heme. In light of this observation, discuss whether myoglobin should be considered an allosteric protein.
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